Muscle and Gastro-intestinal tract interaction 

Gastrointestinal bypass, insulin sensitivity and mitochondrial function:
Overall aim: Molecular, mechanistic elucidation of changes induced by gastric bypass operation in mitochondrial function and insulin action in skeletal muscle and fat as studied by euglycemic clamps in man at different time points after surgery and compared to changes in gut hormone profiles.

Erik Richter, Professor
Sten Madsbad, Professor 
Bente Kiens, Professor 
Jørgen Wojtaszewski, Professor 
Flemming Dela, Professor 
Bente Stallknecht, Associate Professor 
Thorkild Ploug, Associate Professor
Jens Juul Holst, Professor

Linking muscle and gut signalling in metabolic syndrome:
Overall aim: Establishing specific and common epigenetic marks and signaling pathways linked to metabolic syndrome by comparing global gene expression, DNA methylation, and histone modifications in the resting vs. exercising and trained muscle in man and in patients undergoing gastric bypass.

Bente Klarlund Pedersen, Professor
Jens Juul Holst, Professor
Niels Tommerup, Professor
Sten Madsbad, Professor

Lipid-induced insulin resistance: reversibility by physical activity and susceptibility by aging?
Overall aim: Characterization of the combined effect of short and long term exposure to high fat diet, age and exercise on expression, function and subcellular localization of molecular targets involved in insulin action in skeletal muscle and fat in man. 

Bente Kiens, Professor
Jørgen Wojtaszewski, Professor 
Erik Richter, Professor
Flemming Dela, Professor
Jens Juul Holst, Professor 
Lars O. Dragsted, Professor 
Niels Tommerup, Professor 

Fitness and Muscle 

Regulation of muscle substrate metabolism and insulin sensitivity: molecular mechanisms activated by exercise.
Overall aim: Characterization of molecular targets including AMPK and its downstream targets involved in exercise-induced changes in substrate oxidation, gene expression and insulin sensitivity in rodents and man. 

Jørgen Wojtaszewski, Professor 
Erik Richter, Professor 
Bente Kiens, Professor 
Bente Stallknecht, Associate Professor

Molecular mechanisms defining the range of insulin sensitivity within the population at large:
Overall aim: Identification of the molecular mechanisms responsible for the large variation in insulin sensitivity in the human population with focus on the function of the T-tubule system, ER stress and lipid toxicity in skeletal muscle. 

Thorkild Ploug, Associate Professor
Bente Stallknecht, Associate Professor
Lars O. Dragsted, Professor
Søren Balling Engelsen, Professor 

Metabolic and Cardiovascular health risks and benefits with profound changes in daily physical activity:
Overall aim: Characterization of metabolic and cardiovascular health risks and benefits after physical inactivity and subsequent rehabilitation in subjects with impaired glucose tolerance and in patients with type 2 diabetes. 

Flemming Dela, Professor
Niels Tommerup, Professor
Thomas Mandrup-Poulsen, Professor 

Dose-response effect of exercise training on metabolic health and appetite in overweight men:
Overall aim: Identify the metabolic health benefits both at the integrative and molecular level of moderate versus high volume exercise training in man - including effects on energy intake, appetite and appetite regulating gut hormones. 

Bente Stallknecht, Associate Professor
Thorkild Ploug, Associate Professor
Jens Juul Holst, Professor
Thomas Mandrup-Poulsen, Professor
Anders Sjödin, Associate Professor
Erik Richter, Professor
Jørgen Wojtaszewski, Professor 
Harald S Hansen, Professor 

Endurance training, psychosocial intervention, gut hormones and glucose tolerance:
Overall aim: Assessing the effect of endurance training and moderate intensity training versus physical inactivity on GLP-1 mediated insulin responses. 

Bente Klarlund Pedersen, Professor
Jens Juul Holst, Professor 

Dog models of fitness:
Overall aim: Comparing global gene expression, DNA methylation, and chromatine status in muscles from dogs before and during a 4 month exercise program (long term effects) as well as before and after acute training and to compare identified genes with those identified in human. 

Charlotte Bjørnvad, Associate Professor
Annemarie Thuri Kristensen, Professor
Merete Fredholm, Professor
Niels Tommerup, Professor