Projects within Gastro-intestinal theme – University of Copenhagen

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Food, Fitness & Pharma > Research > Gastro-intestinal theme

Gastro-intestial themeProjects within Gastro-intestinal theme

Gastro intestinal signals are involved in appetite and blood glucose regulation, and a cornerstone in the curative effects of bariatric surgery in the treatment of type 2 diabetes and obesity. Expected outcome of the research is a detailed mapping of the signals, receptors and mechanisms responsible for these effects. The research impact will be a better understanding of the complex effect and mechanisms of various foods, gut microbiota and gastric bypass operations and could lead to development of novel dietary regimes, probiotics of drugs for use in prevention and treatment of obesity and type-2 diabetes.

The list of publications was last updated in June 2015, and only include publications accepted before that date.

No. UNIK Project title and overall aim Involved research partners 

Bariatric Surgery 

 1

Resolution of type 2 diabetes after bariatric surgery:
Overall aim: Identifying the role of especially gut hormones, metabolites and inflammatory markers in the short and long term beneficial effects of Roux-en-Y gastric bypass surgery in man on type 2 diabetes using meal tests, glucose clamps as well as proteomic analysis. 

Sten Madsbad, Professor 
Jens Juul Holst, Professor 
Thomas Mandrup-Poulsen, Professor 

 

Publications for project 1:

PhD's for project 1:

 2

Effect of Roux-en-Y gastric bypass (RYGB) surgery on energy metabolism:
Overall aim: Determine short-term and long-term effects of RYGB surgery on energy expenditure, appetite regulation and body composition in obese, non-diabetic individuals, and investigate how this relates to the fasting and meal-induced changes in gastrointestinal hormones that are seen following RYGB. 

Arne Astrup, Professor
Sten Madsbad, Professor 
Jens Juul Holst, Professor 

PhD's for project 2:

  • Julie Berg Schmidt
 3

Pig models to study nutrition-mediated gut-brain peptide signalling:
Overall aim: Determine gut hormone release, nutrient balance and organ structure in novel pig models of gastric bypass and ileal resection and in in vitro models of isolated perfused pig stomach and ileum. 

Per Torp Sangild, Professor
Axel Kornerup Hansen, Professor
Jens Juul Holst, Professor
Merete Fredholm, Professor 
Lars O. Dragsted, Professor 

Publications for project 3:

PhD's for project 3:

Food and GI Tract 

 4 

Soluble plant fibres from foods and their metabolic/satiety signalling:
Overall aim: Perform a human cross-over dietary intervention study with selected well-characterized plant fibers and monitor gut hormone signalling over different time intervals. The study includes a comparison with social psychological interventions in project 26. 

Lars O. Dragsted, Professor
Susanne Bügel, Associate Professor
Bo Jacobsen, Professor
Søren Balling Engelsen, Professor 

Publications for project 4:

PhD's for project 4:

 5

Effects of intravenous infusions of gut hormones on energy expenditure and appetite regulation in healthy obese subjects:
Overall aim: Investigating the effect of infusion of appetite regulating hormones singly and in combination on appetite regulation and energy expenditure measured by the ventilated hood method in man. 

Arne Astrup, Professor
Jens Juul Holst, Professor
Thue W Schwartz, Professor 

Publications for project 5

 PhD's for project 5

 6

Gut microbiota and low-grade inflammation in Type 2 diabetes:
Overall aim: Determine the effect of antibiotic treatment with or without probiotic supplementation on gut microbiota, inflammatory markers, insulin and incretin secretion, glucose disposal and fat, liver, muscle and islet macrophage infiltration, growth and exercise capacity in spontaneous animal models of obesity and Type 2 diabetes. 

Thomas Mandrup-Poulsen, Professor
Axel Kornerup Hansen, Professor
Annemarie Thuri Kristensen, Professor
Charlotte Bjørnvad, Associate Professor 
Finn Kvist Vogensen, Associate Professor 
Jens Juul Holst, Professor
Niels Tommerup, Professor 

Publications for project 6:

PhDs for project 6:

 7

Formation of Advanced Glycation End Products (AGE) in food and in the GI-tract:
Overall aim: Identify reaction mechanisms responsible for formation and reactivity of advanced glycation end products (AGE), and develop analytical methods to follow the kinetics of formation of AGE products in food and GI tract. 

Leif Horsfelt Skibsted, Professor
Lars O. Dragsted, Professor
Susanne Bügel, Associate Professor 

Publications for project 7:

 8

Metabolic signalling  by Advanced Glycation End products (AGE) from foods:
Overall aim: Identify major biomarkers of a diet high in advanced glycation end products (AGE) by metabolomics in a short-term rat study and apply these markers in a human dietary study with monitored gut hormone signalling. 

Lars O. Dragsted, Professor
Susanne Bügel
Leif Horsfelt Skibsted, Professor
Jens Juul Holst, Professor
Birgitte Holst, Forskningslektor 
John Nielsen, Professor

Publications for project 8:

PhD's for project 8:

Pharma 

 9

Characterization of the complete hormonal and chemo-sensor repertoire of the enteroendocrine system:
Overall aim: Genetically tag and purify selected prototypes and the collective repertoire of enteroendocrine cells from transgenic mice to characterize their expression of regulatory chemosensors (potential drug targets) and peptide hormones (potential biopharma-ceuticals) through proteomic and expressomic analysis. 

Thue W Schwartz, Professor
Birgitte Holst, Forskningslektor
Niels Tommerup, Professor
Jens Juul Holst, Professor 

Publications for project 9:

 PhDs for proejct 9:

 10

Functional in vitro and in vivo characterization of entero-endocrine sensors of nutrients and food components as potential drug targets:
Overall aim: Molecuar pharmacological characterization of enteroendocrine chemosensors in vitro and generation and phenotypic characterization of knock out mouse models for selected chemosensors: GPR119(N-acylethanolamine), GPR131(TGR5 - bileacids), GPR41/43(short chain fatty acids) and GPR92/93 (proteolytic products). 

Birgitte Holst, Forskningslektor
Thue W Schwartz, Professor
Jens Juul Holst, Professor
Harald S Hansen, Professor
Erik Richter, Professor
Jørgen Wojtaszewski, Professor
Lars O. Dragsted, Professor 

Publications for project 10:

PhD's for project 10:

 11

GI-tract derived lipid ligands controlling metabolism through enteroendocrine, pancreatic and CNS receptors:
Overall aim: Synthesis and characterization of the function of GI tract derived lipid messengers - with special focus on N-acyl-phosphatidylethanol-amine (NAPE) and its hydrolysis products. Selected lipids will be tested in vitro on various receptors in particular GPR119 and in vivo on food intake and appetite hormone secretion. 

Harald S Hansen, Professor
Jens Juul Holst, Professor
Thue W Schwartz, Professor
Mette Rosenkilde, Professor 

Publications for project 11:

PhD's for project 11:

 12

The physiological role of the GPRC6A receptor:
Overall aim: Characterization of the physiological role of the amino acid receptor GPRC6A with special focus on its role in regulation of food intake and metabolism including studies in knock out animals. 

Hans Bräuner-Osborne, Professor
Jens Juul Holst, Professor
Birgitte Holst, Forskningslektor 

Publications for project 12:

 PhD's for project 12:

 PhD's for the Gastro Intestinal Theme