Projects within Genetic Epidemiology – University of Copenhagen

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Genetic EpidemiologyProjects within Genetic Epidemiology

Both genes and environment contribute to obesity, but how they interact is largely unknown. Expected outcome of the research is more detailed and enhanced information on how the combination of genes and environment interacts in the development of obesity and lifestyle diseases. This information will have impact on the basis for understanding and ultimately reducing the development of the obesity epidemic.

The list of publications was last updated in June 2015, and only include publications accepted before that date.

No. UNIK Project title and overall aim Involved research partners 

Genetic Epidemiology 

 27

Studies of metabolic and cardiovascular health genetics and the interaction with health behaviour and socioeconomics in the DCH cohort based upon LuCAMP derived exome discoveries:
Overall aim: Genotyping initially in a case-cohort context subsequently in the whole DCHC of novel gene variations derived from the exome sequencing in patients suffering from visceral obesity, hypertension and type-2 diabetes aiming at demonstrating association to common metabolic and cardiovascular morbidity and mortality as well as gene-environment interactions in relation to these diseases. 

Oluf Borbye Pedersen, Professor
Thorkild I.A. Sørensen, Professor
Anne Tjønneland (Kræftens Bekæmpelse)
Kim Overvad (Århus Universitet)

Publications for project 27:

PhD's from project 27

 28

Genes interacting with dietary factors in determining body weight changes and eventual development of obesity:
Overall aim: To investigate whether the gene variations derived from genome-wide association studies and genome-wide exon sequencing are interacting with a variety of dietary factors in determining the changes in body weight and waist over time, with particular focus on development of various forms of obesity (general, peripheral,
abdominal) using a cohort case-control/sub-cohort approach in the DCHC.

Thorkild I.A. Sørensen, Professor
Oluf Borbye Pedersen, Professor
Anne Tjønneland (Kræftens Bekæmpelse)
Kim Overvad (Århus Universitet)

Publications for project 28:

PhD's for project 28:

 29

Studies of metabolic and cardiovascular health genetics: Establishment of a pig resource population:
Overall aim: Identify the genomic regions that comprise components underlying the distinct phenotypes that deviate between well defined pig breeds varying in their proneness to obesity and glycemic control and to study the influence of identified genes on metabolic and cardiovascular health in the DCH cohort.

Merete Fredholm, Professor
Axel Kornerup Hansen, Professor
Niels Tommerup, Professor 
Per Torp Sangild, Professor
Oluf Borbye Pedersen, Professor
Anne Tjønneland (Kræftens 
Bekæmpelse)
Thorkild I.A. Sørensen, Professor
Torben Hansen, Professor

Publications for project 29: