PhD - Kim Anker Sjøberg – University of Copenhagen

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Kim Anker Sjøberg, PhD

Department of Nutrition, Exercise and Sports

Affiliated with UNIK project no. 15

Title of thesis: Microvascular recruitment in insulin resistance

About the thesis: In this PhD work a new method for measuring perfusion of skeletal muscle (microvascular recruitment) was developed and evaluated, using continues real-time imaging of contrast enhanced ultrasound. This method was applied to investigate the vaso-active effect of both insulin and the incretin hormone glucagon-like-peptide-1 (GLP-1) in the microcirculation. Glucagon-like-peptide-1 analogs are drugs used for treatments of insulin resistance and type 2 diabetes but the vascular effects of GLP-1 in vivo are elusive.
Here we observed, like insulin, GLP-1 increased microvascular recruitment but unlike insulin no direct effect on muscle glucose uptake of GLP-1 was observed.


Kim Anker Sjøberg at PubMed


Kim Anker Sjøberg at LinkedIn